Historically, the adenomas were recognized as lesions less than 3 cm based on the work of Bell. This was later modified identified in 1970 by Murphy and Mostofi who felt that the histological differentiation of Aden carcinomas adenomas was true possible. Renal papillary adenomas are small, discrete, and arise from renal tubular epithelium. In autopsy studies, increasing in frequency with age (7-40%).
Pathology
In the most recent WHO classification, papillary adenomas are less than 5 mm in diameter with a low nuclear grade. They appear as pale yellow, gray, well circumscribed nodules, usually below the renal capsule in the renal cortex. They usually not encapsulated, however, some have thin pseudo capsule. In microscopic examination, which have tubular architecture, papillary or tubular-like papillary renal cell carcinoma. The cells have scant cytoplasm, round to oval nuclei and have high nuclear grade (Fuhrman nuclear grade 3 or 4). Cytogenetics Features include trisomy (chromosome 7 and 17) and the loss of similarity chromosome. The And in this tumor with papillary renal cell carcinoma has led to the view that it may represent a precursor lesion for CRC.
Clinical presentation and treatment
Most of these lesions are discovered accidentally. They tend to occur more frequently in patients with underlying kidney disease related to atherosclerosis, scarring, acquired renal cystic disease secondary to hemodialysis, and other malignancy prevailing conditions of the kidney.
With small tumors incidentally detected increasingly during radiological procedures, the current view is to consider them all as probable early cancer to a clear marker of benignity is discovered. Renal tumors with diameters of 0.5 to 2 cm often behave sluggish, although the biologic behavior is difficult to determine, so that tumors less than 2 cm
They are sometimes called "renal epithelial tumors of uncertain malignant potential, and observed for progression, while Larger tumors may require surgical removal, depending on the clinical scenario. There is no defined role for radiation therapy or chemotherapy in the treatment of renal papillomas.
Pathology
In the most recent WHO classification, papillary adenomas are less than 5 mm in diameter with a low nuclear grade. They appear as pale yellow, gray, well circumscribed nodules, usually below the renal capsule in the renal cortex. They usually not encapsulated, however, some have thin pseudo capsule. In microscopic examination, which have tubular architecture, papillary or tubular-like papillary renal cell carcinoma. The cells have scant cytoplasm, round to oval nuclei and have high nuclear grade (Fuhrman nuclear grade 3 or 4). Cytogenetics Features include trisomy (chromosome 7 and 17) and the loss of similarity chromosome. The And in this tumor with papillary renal cell carcinoma has led to the view that it may represent a precursor lesion for CRC.
Clinical presentation and treatment
Most of these lesions are discovered accidentally. They tend to occur more frequently in patients with underlying kidney disease related to atherosclerosis, scarring, acquired renal cystic disease secondary to hemodialysis, and other malignancy prevailing conditions of the kidney.
With small tumors incidentally detected increasingly during radiological procedures, the current view is to consider them all as probable early cancer to a clear marker of benignity is discovered. Renal tumors with diameters of 0.5 to 2 cm often behave sluggish, although the biologic behavior is difficult to determine, so that tumors less than 2 cm
They are sometimes called "renal epithelial tumors of uncertain malignant potential, and observed for progression, while Larger tumors may require surgical removal, depending on the clinical scenario. There is no defined role for radiation therapy or chemotherapy in the treatment of renal papillomas.